Kidney epithelium development

Across TCGA patient cohorts, RNA activity of the Kidney epithelium development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KANK2, TLN2, and ZEB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Kidney epithelium development activity versus KANK2 in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KANK2 →	+0.508	+0.362	.003	.005	3	7
PDAC	TLN2 →	+0.550	+0.787	<.001	.002	3	6
BRCA	ZEB1 →	+0.688	+0.367	.001	.004	3	6
OV	PTH1R →	+0.614	+0.380	.004	.008	3	6
PDAC	MOV10L1 →	+0.365	+0.701	<.001	<.001	3	6
BRCA	HMGA1 →	-0.839	-0.411	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072073 vs KANK2 — BRCA

Explore this scatter interactively →