Proximal/distal pattern formation involved in nephron development

Across TCGA patient cohorts, RNA activity of the Proximal/distal pattern formation involved in nephron development pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TIMP1, DOCK8, and IRX2_S317, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proximal/distal pattern formation involved in nephron development activity versus TIMP1 in COAD (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TIMP1 →	+0.692	+0.519	<.001	.003	3	4
LSCC	DOCK8 →	-0.315	-0.133	<.001	.003	3	4
BRCA	IRX2_S317 →	+1.008	+0.132	.003	<.001	3	4
CCRCC	TNS3 →	-0.207	-0.245	<.001	.007	3	4
UCEC	HSPB8 →	+0.793	+0.750	<.001	<.001	3	4
UCEC	BAG3 →	+0.326	+0.497	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072047 vs TIMP1 — COAD

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