Proximal/distal pattern formation involved in nephron development

Across TCGA patient cohorts, RNA activity of the Proximal/distal pattern formation involved in nephron development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRX2, LRRFIP2, and C5orf38, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Proximal/distal pattern formation involved in nephron development activity versus IRX2 in BRCA (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IRX2 →	+1.643	+0.471	<.001	<.001	3	5
GBM	LRRFIP2 →	+0.220	+0.415	.002	.006	3	4
BRCA	C5orf38 →	+1.677	+0.701	<.001	<.001	3	4
GBM	INTS6L →	+0.315	+0.446	.003	.008	3	3
GBM	TMEM254-AS1 →	+0.481	+0.474	<.001	.001	3	3
GBM	USP51 →	+0.569	+0.504	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072047 vs IRX2 — BRCA

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