Distal convoluted tubule development

Across TCGA patient cohorts, RNA activity of the Distal convoluted tubule development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KNOP1, XPO5, and MCM4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Distal convoluted tubule development activity versus KNOP1 in UCEC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KNOP1 →	+0.432	+0.626	.004	.009	3	3
CCRCC	XPO5 →	+0.225	+0.586	.006	.003	3	3
UCEC	MCM4 →	+0.719	+0.750	.001	<.001	3	3
OV	PGBD4P1 →	+0.276	+0.420	<.001	.009	3	2
CCRCC	ITGB8 →	+1.136	+0.615	<.001	.008	3	2
CCRCC	URB2 →	+0.382	+0.678	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072025 vs KNOP1 — UCEC

Explore this scatter interactively →