Distal convoluted tubule development

Across TCGA cell cohorts, RNA activity of the Distal convoluted tubule development pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGB4, NOG, and FRYL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGB4 grouped by Distal convoluted tubule development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ITGB4 →	+0.198	+0.949	.004	.003	3	4
URINARY_TRACT	NOG →	-0.275	-2.430	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	FRYL →	+0.240	+1.607	.004	.003	3	4
BREAST	BBOX1 →	+0.127	+1.034	.007	<.001	3	3
BREAST	VAV2 →	+0.141	+0.957	.002	.003	2	4
BREAST	UTF1 →	-0.197	-1.582	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGB4 by Distal convoluted tubule development activity — BREAST

Explore this box plot interactively →