Nephron epithelium development

Across TCGA patient cohorts, RNA activity of the Nephron epithelium development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NR2F2-AS1, JAM3, and KANK2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nephron epithelium development activity versus NR2F2-AS1 in CCRCC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NR2F2-AS1 →	+0.532	+0.517	.003	.003	3	6
BRCA	JAM3 →	+0.783	+0.737	<.001	<.001	3	6
BRCA	KANK2 →	+0.781	+0.665	<.001	<.001	2	7
LUAD	NCAPG →	-1.035	-0.809	<.001	.001	3	5
LUAD	CDCA8 →	-0.954	-0.767	<.001	.005	3	5
LUAD	KIF11 →	-0.899	-0.951	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0072009 vs NR2F2-AS1 — CCRCC

Explore this scatter interactively →