Nephron epithelium development

Across TCGA pan-cancer cohorts, RNA activity of the Nephron epithelium development pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 120 member genes.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher Nephron epithelium development pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and GBM, show the opposite pattern, with higher activity associated with better survival.

BRCA, ACC, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	III,IV	0.863	0.731	.002	47	view →
ACC	DFS	Median	IV	0.154	0.493	.004	40	view →
MESO	OS	Tertile	All	0.394	0.627	.002	38	view →
GBM	OS	Median	All	0.500	0.326	.001	36	view →
LUAD	OS	Median	II,III,IV	0.701	0.504	.010	27	view →
ESCA	DFS	Quartile	III,IV	0.653	0.261	.011	24	view →
HNSC	DFS	Tertile	IV	0.727	0.533	.001	18	view →
READ	DFS	Tertile	IV	0.199	0.647	.003	15	view →
KIRC	OS	Quartile	II,III,IV	0.738	0.611	.017	14	view →
LUSC	DFS	Tertile	III,IV	0.100	0.739	.033	12	view →
UVM	OS	Median	All	0.945	0.485	.009	12	view →
COAD	DFS	Tertile	IV	0.334	0.544	.032	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0072009–BRCA (DFS)

Open the BRCA breakdown →