Mesangial cell differentiation

Across TCGA cell cohorts, RNA activity of the Mesangial cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXC2, APBA2, and PROSER1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FOXC2 grouped by Mesangial cell differentiation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FOXC2 →	-0.446	-1.725	<.001	<.001	3	11
BLOOD_Myeloma	APBA2 →	+0.419	+1.423	.006	.001	3	6
SKIN	PROSER1 →	-0.170	-1.088	.001	<.001	3	5
LUNG_NSCLC_LUAD	OSR1 →	-0.228	-1.408	<.001	<.001	3	4
BLOOD_Leukemia	BAP1 →	+0.258	+1.101	.001	.001	3	4
PANCREAS	GAS7 →	+0.249	+0.797	.007	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FOXC2 by Mesangial cell differentiation activity — BONE

Explore this box plot interactively →