Mesangial cell differentiation

Across TCGA cell cohorts, RNA activity of the Mesangial cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OR2H1, PGAM1, and TP53, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OR2H1 grouped by Mesangial cell differentiation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR2H1 →	-0.339	-0.264	.005	.006	2	5
PANCREAS	PGAM1 →	-0.251	-1.010	.008	.003	2	5
SOFT_TISSUE	TP53 →	-0.789	-0.208	<.001	.009	3	4
SKIN	VN1R1 →	-0.293	-0.895	.002	.006	3	4
OVARY	PRDM1 →	-0.311	-1.142	.002	<.001	3	4
LUNG_SCLC	CD79A →	+0.180	+0.949	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OR2H1 by Mesangial cell differentiation activity — SOFT_TISSUE

Explore this box plot interactively →