"Mitotic sister chromatid cohesion, centromeric"

Across TCGA cell cohorts, RNA activity of the "Mitotic sister chromatid cohesion, centromeric" pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR1F, SPR, and CLIP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLR1F grouped by "Mitotic sister chromatid cohesion, centromeric"-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	POLR1F →	-0.203	-0.123	.002	<.001	3	5
BREAST	SPR →	-0.382	-0.117	.002	.002	3	5
OESOPHAGUS	CLIP4 →	+0.152	+0.163	.005	.006	3	4
URINARY_TRACT	SLC39A4 →	+0.330	+0.167	.005	<.001	3	4
OVARY	NR1H4 →	-0.187	-0.088	.001	.003	3	4
SOFT_TISSUE	SRPRB →	-0.183	-0.157	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLR1F by "Mitotic sister chromatid cohesion, centromeric" activity — KIDNEY

Explore this box plot interactively →