Determination of digestive tract left/right asymmetry

Across TCGA patient cohorts, RNA activity of the Determination of digestive tract left/right asymmetry pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPATA9, RPL9P14, and EEF1A1P32, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Determination of digestive tract left/right asymmetry activity versus SPATA9 in LUAD (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SPATA9 →	-0.239	-0.723	<.001	<.001	3	2
LUAD	RPL9P14 →	-0.092	-0.449	.008	.007	3	2
LUAD	EEF1A1P32 →	-0.300	-0.479	.001	.004	3	2
LUAD	PHF5GP →	-0.575	-0.447	.004	.008	3	2
LUAD	IL10RB →	-0.191	-0.467	.006	.005	3	2
LUAD	FZD10-AS1 →	+0.374	+0.463	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071907 vs SPATA9 — LUAD

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