Determination of digestive tract left/right asymmetry

Across TCGA cell cohorts, RNA activity of the Determination of digestive tract left/right asymmetry pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A13, ACP2, and OIT3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC25A13 grouped by Determination of digestive tract left/right asymmetry-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SLC25A13 →	-1.091	-0.957	.004	.002	3	3
LUNG_NSCLC_LUSC	ACP2 →	-1.335	-0.439	.001	.003	3	3
LUNG_NSCLC_LUSC	OIT3 →	-0.048	-0.360	.002	.008	3	3
LUNG_NSCLC_LUSC	GDPGP1 →	-0.656	-0.332	.001	<.001	3	3
OESOPHAGUS	COPS5 →	-0.960	-0.337	.003	.001	3	3
OESOPHAGUS	ZNF426 →	-1.637	-0.316	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC25A13 by Determination of digestive tract left/right asymmetry activity — SOFT_TISSUE

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