Regulation of protein serine/threonine kinase activity

Across TCGA patient cohorts, RNA activity of the Regulation of protein serine/threonine kinase activity pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNTB2_S222, COG7, and LCP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein serine/threonine kinase activity activity versus SNTB2_S222 in GBM (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNTB2_S222 →	+0.929	+0.030	<.001	<.001	3	7
UCEC	COG7 →	-0.198	-0.038	.005	.003	3	7
GBM	LCP2 →	+0.369	+0.026	<.001	<.001	3	7
BRCA	NCF4 →	+0.415	+0.025	.002	.001	3	7
UCEC	RENBP →	+0.380	+0.046	<.001	<.001	3	7
GBM	IL16 →	+0.650	+0.038	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071900 vs SNTB2_S222 — GBM

Explore this scatter interactively →