DNA biosynthetic process

Across TCGA patient cohorts, RNA activity of the DNA biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATAD2, CRNKL1, and MCM2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA biosynthetic process activity versus ATAD2 in HNSC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ATAD2 →	+0.473	+0.070	<.001	.004	3	7
LSCC	CRNKL1 →	+0.269	+0.043	<.001	<.001	3	7
LUAD	MCM2 →	+0.628	+0.045	<.001	<.001	3	7
LUAD	MCM6 →	+0.641	+0.045	<.001	<.001	3	7
GBM	MCM7 →	+0.721	+0.028	<.001	<.001	3	7
LUAD	CHAF1A →	+0.378	+0.037	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071897 vs ATAD2 — HNSC

Explore this scatter interactively →