Protein localization to adherens junction

Across TCGA patient cohorts, RNA activity of the Protein localization to adherens junction pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MINDY3, HEPH, and ITGBL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to adherens junction activity versus MINDY3 in LUAD (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MINDY3 →	+0.236	+0.659	.001	<.001	3	5
CCRCC	HEPH →	+0.442	+0.417	.009	.005	3	5
CCRCC	ITGBL1 →	+1.226	+0.701	<.001	.001	3	5
BRCA	MXRA8 →	+0.642	+0.499	.004	.004	3	5
BRCA	DKK3 →	+0.970	+0.783	<.001	.001	3	5
BRCA	TIMP3 →	+1.201	+0.837	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071896 vs MINDY3 — LUAD

Explore this scatter interactively →