Leukocyte apoptotic process

Across TCGA cell cohorts, RNA activity of the Leukocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP1, ITPK1, and MYO6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukocyte apoptotic process activity versus MMP1 in SOFT_TISSUE (Pearson r = -0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MMP1 →	-5.718	-1.032	.003	.007	3	5
STOMACH	ITPK1 →	+1.405	+1.367	.001	<.001	3	4
STOMACH	MYO6 →	+2.275	+1.350	.001	<.001	3	4
LIVER	TP53TG3 →	-1.434	-1.310	.004	<.001	3	3
BLOOD_Lymphoma	ACP3 →	-1.710	-0.484	.003	.009	3	3
STOMACH	LGALS4 →	+6.901	+1.242	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071887 vs MMP1 — SOFT_TISSUE

Explore this scatter interactively →