Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAPBP, MTND3P1, and BANF1P4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway activity versus TAPBP in CCRCC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TAPBP →	-0.580	-0.370	<.001	.008	3	4
OV	MTND3P1 →	-0.271	-0.505	.002	.008	3	4
OV	BANF1P4 →	-0.784	-0.482	<.001	<.001	3	3
BRCA	ZNF587P1 →	-0.055	-0.154	.007	.005	3	3
LUAD	CGRRF1 →	+0.379	+0.287	<.001	.002	3	3
CCRCC	TROAP →	-0.553	-0.457	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071878 vs TAPBP — CCRCC

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