Cellular response to epinephrine stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to epinephrine stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SELENOM, RSF1_S397, and SH3BGRL3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to epinephrine stimulus activity versus SELENOM in GBM (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SELENOM →	+0.474	+0.075	.002	.001	3	6
LUAD	RSF1_S397 →	-0.500	-0.039	.001	<.001	3	5
GBM	SH3BGRL3 →	+0.322	+0.075	<.001	<.001	3	5
GBM	SYK →	+0.385	+0.066	<.001	<.001	3	5
GBM	ACTR3 →	+0.211	+0.063	<.001	.001	3	5
BRCA	ZNF24 →	-0.272	-0.049	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071872 vs SELENOM — GBM

Explore this scatter interactively →