Cellular response to epinephrine stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to epinephrine stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGS2, IL18R1, and MANBAL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RGS2 grouped by Cellular response to epinephrine stimulus-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RGS2 →	+1.717	+0.924	.004	.007	3	4
LUNG_NSCLC_LUSC	IL18R1 →	-0.994	-1.088	.001	.004	3	3
LARGE_INTESTINE	MANBAL →	+0.780	+1.057	<.001	.003	3	3
LARGE_INTESTINE	PDLIM5 →	+0.814	+0.919	.002	<.001	3	3
LARGE_INTESTINE	ANXA5 →	+1.185	+0.923	.009	.004	3	3
KIDNEY	CAPZA1 →	-0.680	-1.416	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RGS2 by Cellular response to epinephrine stimulus activity — LARGE_INTESTINE

Explore this box plot interactively →