Cellular response to epinephrine stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to epinephrine stimulus pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SSU72, ATP7B, and SPAG1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to epinephrine stimulus activity versus SSU72 in PANCREAS (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SSU72 →	+0.735	+1.179	.001	.003	3	4
OESOPHAGUS	ATP7B →	-1.965	-0.460	.002	.004	3	4
OVARY	SPAG1 →	-1.499	-0.735	.002	.008	3	3
OVARY	ACAP3 →	+1.064	+0.752	<.001	.009	3	3
OVARY	PLCXD2 →	-2.643	-0.786	<.001	.005	3	3
SKIN	TRAK1 →	+0.508	+0.858	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071872 vs SSU72 — PANCREAS

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