Response to epinephrine

Across TCGA cell cohorts, RNA activity of the Response to epinephrine pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO21, ATP7B, and ZNF551, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to epinephrine activity versus FBXO21 in BLOOD_Leukemia (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FBXO21 →	-1.510	-0.621	.002	.001	3	4
OESOPHAGUS	ATP7B →	-1.965	-0.505	.002	.003	3	4
BLOOD_Lymphoma	ZNF551 →	-1.569	-0.364	<.001	<.001	3	4
PANCREAS	SSU72 →	+0.734	+1.230	.001	.002	3	4
BREAST	MADD →	-0.670	-0.307	.002	.009	3	3
BREAST	PASK →	-0.777	-0.313	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071871 vs FBXO21 — BLOOD_Leukemia

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