Regulation of apoptotic process in bone marrow cell

Across TCGA patient cohorts, RNA activity of the Regulation of apoptotic process in bone marrow cell pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCAN_S2116, HMCN1, and HIC1_S237, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of apoptotic process in bone marrow cell activity versus VCAN_S2116 in HNSC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	VCAN_S2116 →	+1.148	+0.104	<.001	.001	3	7
LSCC	HMCN1 →	+0.541	+0.132	<.001	<.001	3	7
HNSC	HIC1_S237 →	+0.496	+0.086	<.001	<.001	3	7
LSCC	SARM1 →	+0.271	+0.081	.008	.005	3	6
LSCC	VCL_S346 →	+0.592	+0.121	<.001	<.001	3	6
UCEC	LEF1 →	+0.938	+0.213	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071865 vs VCAN_S2116 — HNSC

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