Regulation of apoptotic process in bone marrow cell

Across TCGA cell cohorts, RNA activity of the Regulation of apoptotic process in bone marrow cell pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are REV3L, BAMBI, and TMEM229B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, REV3L grouped by Regulation of apoptotic process in bone marrow cell-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	REV3L →	+0.896	+1.050	<.001	<.001	3	5
SKIN	BAMBI →	+1.875	+1.194	.001	<.001	3	5
CNS	TMEM229B →	+0.874	+0.864	.001	<.001	3	5
LARGE_INTESTINE	POU6F1 →	+1.012	+1.419	<.001	<.001	2	6
LUNG_SCLC	DSTYK →	+1.051	+1.595	<.001	.001	3	4
SOFT_TISSUE	USP46 →	+0.885	+1.329	.008	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

REV3L by Regulation of apoptotic process in bone marrow cell activity — SKIN

Explore this box plot interactively →