Regulation of cell proliferation in bone marrow

Across TCGA patient cohorts, RNA activity of the Regulation of cell proliferation in bone marrow pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LARP4B_S664, LEF1, and SRRM2_S743, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell proliferation in bone marrow activity versus LARP4B_S664 in BRCA (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LARP4B_S664 →	-0.336	-0.050	.003	.006	3	5
GBM	LEF1 →	+0.785	+0.079	<.001	<.001	3	5
COAD	SRRM2_S743 →	-0.622	-0.064	.004	.005	3	4
BRCA	IMPA2 →	-0.589	-0.064	.004	.001	3	4
CCRCC	NCAPH →	-0.582	-0.100	<.001	<.001	3	4
GBM	EIF2S2 →	-0.186	-0.091	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071863 vs LARP4B_S664 — BRCA

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