Regulation of cell proliferation in bone marrow

Across TCGA cell cohorts, RNA activity of the Regulation of cell proliferation in bone marrow pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPDZ, IGFBPL1, and TRIM54, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell proliferation in bone marrow activity versus MPDZ in OESOPHAGUS (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MPDZ →	+3.639	+2.080	.005	.001	3	2
OESOPHAGUS	IGFBPL1 →	+0.940	+2.144	.007	<.001	3	2
BLOOD_Leukemia	TRIM54 →	+0.120	+1.846	.009	<.001	3	2
BLOOD_Leukemia	ESM1 →	+0.075	+2.404	.004	.004	3	2
OESOPHAGUS	SPATA24 →	+1.119	+2.128	.009	.002	3	2
OESOPHAGUS	CCDC28B →	+2.329	+2.108	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071863 vs MPDZ — OESOPHAGUS

Explore this scatter interactively →