Apoptotic process in bone marrow cell

pathway activity — cross-omics
GO:0071839Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Apoptotic process in bone marrow cell pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HMCN1, TLN2, and VCAN_S2116, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMHMCN1 →+0.606+0.085<.001<.00137
LSCCTLN2 →+0.404+0.099<.001<.00136
LSCCVCAN_S2116 →+0.853+0.099.001.00127
HNSCHIC1_S237 →+0.421+0.074<.001<.00136
GBMLEF1 →+0.778+0.088<.001<.00136
GBMPRKG1 →+0.334+0.051<.001.00536
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration