Triglyceride-rich lipoprotein particle clearance

Across TCGA patient cohorts, RNA activity of the Triglyceride-rich lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CR1, LIPA, and DPEP2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Triglyceride-rich lipoprotein particle clearance activity versus CR1 in GBM (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CR1 →	+0.930	+0.085	<.001	.002	3	9
UCEC	LIPA →	+0.672	+0.091	.003	<.001	3	8
LSCC	DPEP2 →	+0.647	+0.076	<.001	<.001	3	8
GBM	MS4A4A →	+0.642	+0.068	.004	<.001	3	8
HNSC	NCKAP1L →	+0.727	+0.089	.004	.004	3	8
CCRCC	CD300LF →	+0.853	+0.129	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071830 vs CR1 — GBM

Explore this scatter interactively →