Triglyceride-rich lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the Triglyceride-rich lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FERMT1, CTSS, and ARL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FERMT1 grouped by Triglyceride-rich lipoprotein particle clearance-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FERMT1 →	-1.799	-1.431	.001	<.001	3	5
KIDNEY	CTSS →	-3.343	-1.281	.004	.003	3	4
KIDNEY	ARL3 →	-0.762	-1.106	.002	.002	3	4
LARGE_INTESTINE	MIPEP →	-1.583	-2.020	.004	<.001	3	4
OESOPHAGUS	APEX1 →	+1.027	+0.967	<.001	.007	3	4
LUNG_SCLC	RAB2B →	+1.321	+1.078	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FERMT1 by Triglyceride-rich lipoprotein particle clearance activity — CNS

Explore this box plot interactively →