Triglyceride-rich lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the Triglyceride-rich lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOC1, APOE, and PLTP, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Triglyceride-rich lipoprotein particle clearance activity versus APOC1 in BLOOD_Leukemia (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	APOC1 →	+4.239	+1.186	<.001	<.001	3	19
LIVER	APOE →	+5.304	+0.709	<.001	.003	3	18
OESOPHAGUS	PLTP →	+4.112	+1.464	<.001	.002	3	13
OESOPHAGUS	ASGR1 →	+0.820	+1.360	.007	.002	3	10
CNS	GAREM2 →	+0.944	+1.680	<.001	<.001	3	10
BONE	SALL2 →	+3.492	+1.436	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071830 vs APOC1 — BLOOD_Leukemia

Explore this scatter interactively →