Triglyceride-rich lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the Triglyceride-rich lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC35F2, RFT1, and CYB5A, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Triglyceride-rich lipoprotein particle clearance activity versus SLC35F2 in BLOOD_Leukemia (Pearson r = 0.99).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC35F2 →	+1.955	+0.325	.007	.007	1	2
BLOOD_Leukemia	RFT1 →	-0.485	-0.325	.001	.007	1	2
BLOOD_Leukemia	CYB5A →	+1.415	+0.325	.001	.007	1	2
BLOOD_Leukemia	SOCS5 →	+0.774	+0.325	.008	.007	1	2
BLOOD_Leukemia	ZNF561 →	+1.279	+0.325	.003	.007	1	2
BLOOD_Leukemia	GRAMD2A →	+0.055	+0.325	.008	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071830 vs SLC35F2 — BLOOD_Leukemia

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