Triglyceride-rich lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the Triglyceride-rich lipoprotein particle clearance pathway is significantly associated with the protein abundance of multiple proteins, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKAR1A, DBN1, and SERPINB6, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Triglyceride-rich lipoprotein particle clearance activity versus PRKAR1A in BONE (Pearson r = -0.89).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PRKAR1A →	-1.276	-1.765	.009	<.001	3	2
BONE	DBN1 →	+0.849	+1.765	.008	<.001	3	2
BONE	SERPINB6 →	-1.723	-1.765	.003	<.001	3	2
BONE	APOL2 →	-1.790	-1.871	<.001	.002	3	2
BONE	DPF2 →	+0.970	+1.871	.002	.002	3	2
BONE	RBM10 →	+0.766	+1.765	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071830 vs PRKAR1A — BONE

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