Protein-RNA complex organization

Across TCGA patient cohorts, RNA activity of the Protein-RNA complex organization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAB3D, UCHL1, and GATAD2B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-RNA complex organization activity versus RAB3D in OV (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RAB3D →	-0.615	-0.031	.006	.003	3	7
UCEC	UCHL1 →	+1.009	+0.088	<.001	.007	3	6
HNSC	GATAD2B →	+0.379	+0.076	<.001	.005	3	6
LSCC	ITPRID2_S767 →	-0.527	-0.045	.002	.001	3	6
HNSC	POGZ →	+0.430	+0.109	<.001	<.001	3	6
HNSC	RCOR3 →	+0.555	+0.092	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071826 vs RAB3D — OV

Explore this scatter interactively →