Protein-RNA complex organization

Across TCGA cell cohorts, RNA activity of the Protein-RNA complex organization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ILF3, RAVER1, and PPAN, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-RNA complex organization activity versus ILF3 in BREAST (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ILF3 →	+0.655	+0.211	.004	<.001	3	8
OVARY	RAVER1 →	+0.720	+0.220	<.001	<.001	3	8
OVARY	PPAN →	+0.913	+0.280	<.001	<.001	3	7
OVARY	SSRP1 →	+0.756	+0.164	<.001	.007	3	7
SKIN	INCENP →	+1.180	+0.242	<.001	.001	3	7
OVARY	WDR43 →	+0.876	+0.277	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071826 vs ILF3 — BREAST

Explore this scatter interactively →