Tail-anchored membrane protein insertion into ER membrane

Across TCGA patient cohorts, RNA activity of the Tail-anchored membrane protein insertion into ER membrane pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COMMD9, MAN2B1, and NOP9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tail-anchored membrane protein insertion into ER membrane activity versus COMMD9 in CCRCC (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	COMMD9 →	-0.131	-0.031	<.001	<.001	3	4
CCRCC	MAN2B1 →	-0.217	-0.030	.002	.003	3	4
LUAD	NOP9 →	+0.244	+0.041	.001	<.001	3	4
COAD	WDR77 →	+0.220	+0.028	<.001	.003	3	4
GBM	ATL1_S10 →	+0.591	+0.045	<.001	<.001	3	4
GBM	SMARCD2 →	-0.244	-0.037	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071816 vs COMMD9 — CCRCC

Explore this scatter interactively →