Protein transmembrane transport

Across TCGA cell cohorts, RNA activity of the Protein transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYFIP2, RHOBTB3, and EWSR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein transmembrane transport activity versus CYFIP2 in BLOOD_Leukemia (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CYFIP2 →	-2.471	-0.107	.001	.009	3	5
BREAST	RHOBTB3 →	+1.982	+0.166	<.001	<.001	3	4
LUNG_SCLC	EWSR1 →	-0.374	-0.100	.001	.006	3	4
LARGE_INTESTINE	HECTD3 →	-0.716	-0.118	<.001	.002	2	5
PANCREAS	ELP6 →	-0.701	-0.208	.007	.006	3	4
BLOOD_Leukemia	FNDC3B →	+1.169	+0.095	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071806 vs CYFIP2 — BLOOD_Leukemia

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