Positive regulation of podosome assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of podosome assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IGF2BP1_S181, MPI, and TOP2A_S1106, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of podosome assembly activity versus IGF2BP1_S181 in LSCC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IGF2BP1_S181 →	+2.076	+0.061	<.001	<.001	3	6
CCRCC	MPI →	-0.558	-0.058	<.001	<.001	3	5
LUAD	TOP2A_S1106 →	+0.898	+0.050	<.001	<.001	3	5
LSCC	ESF1 →	+0.291	+0.062	.004	<.001	3	5
LSCC	RBM28 →	+0.353	+0.061	<.001	<.001	3	5
LUAD	COL3A1 →	+0.475	+0.059	.008	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071803 vs IGF2BP1_S181 — LSCC

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