Positive regulation of podosome assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of podosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH1B1, RAB15, and STT3B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALDH1B1 grouped by Positive regulation of podosome assembly-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ALDH1B1 →	-1.499	-1.448	.007	<.001	3	3
BONE	RAB15 →	-1.625	-1.536	.002	<.001	3	3
BONE	STT3B →	-1.144	-1.413	.008	.007	3	3
BONE	SETMAR →	-1.117	-1.472	.009	<.001	3	3
CNS	COL17A1 →	+1.910	+0.962	.007	.004	3	3
LUNG_NSCLC_LUAD	ANGPTL3 →	-0.118	-0.908	.009	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALDH1B1 by Positive regulation of podosome assembly activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →