Response to prostaglandin D

Across TCGA cell cohorts, RNA activity of the Response to prostaglandin D pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIA1, CCNT1, and KANSL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TIA1 grouped by Response to prostaglandin D-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TIA1 →	-1.046	-1.224	<.001	<.001	3	5
LUNG_SCLC	CCNT1 →	-0.631	-1.063	.002	.009	3	5
LUNG_SCLC	KANSL2 →	-0.770	-1.116	.002	.004	3	5
LUNG_SCLC	SECISBP2 →	-0.993	-1.142	<.001	.001	3	5
LUNG_SCLC	C2orf92 →	-1.347	-0.859	<.001	.005	3	5
STOMACH	DCAF17 →	-0.617	-1.043	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TIA1 by Response to prostaglandin D activity — LUNG_SCLC

Explore this box plot interactively →