Response to prostaglandin D

Across TCGA cell cohorts, RNA activity of the Response to prostaglandin D pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFE2L2, FARSA, and FAM20B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NFE2L2 grouped by Response to prostaglandin D-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NFE2L2 →	+0.191	+0.396	.005	.006	3	6
BLOOD_Leukemia	FARSA →	-0.172	-0.918	.009	.007	3	4
SKIN	FAM20B →	-0.173	-0.970	.001	<.001	3	4
OESOPHAGUS	KCNK6 →	+0.124	+0.433	.002	.001	3	3
SKIN	SALL1 →	-0.155	-0.908	.003	.001	3	3
BLOOD_Leukemia	CEP78 →	-0.168	-0.932	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NFE2L2 by Response to prostaglandin D activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →