Endoplasmic reticulum tubular network organization

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum tubular network organization pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IMPA2, CKS1BP3, and STX12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum tubular network organization activity versus IMPA2 in LSCC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IMPA2 →	-0.591	-0.118	.001	.005	3	6
LSCC	CKS1BP3 →	-0.426	-0.230	.004	<.001	3	6
COAD	STX12 →	+0.343	+0.306	<.001	.008	2	6
OV	TGFB3 →	+1.466	+0.212	<.001	<.001	3	5
GBM	NEGR1 →	+1.083	+0.316	<.001	<.001	3	5
GBM	NAP1L3 →	+0.883	+0.260	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071786 vs IMPA2 — LSCC

Explore this scatter interactively →