Endoplasmic reticulum tubular network organization

Across TCGA cell cohorts, RNA activity of the Endoplasmic reticulum tubular network organization pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSKMT, UBE2R2, and BAZ2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CSKMT grouped by Endoplasmic reticulum tubular network organization-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CSKMT →	-1.205	-1.463	.002	.001	3	5
SKIN	UBE2R2 →	-0.634	-0.789	<.001	.003	3	4
BONE	BAZ2B →	-1.702	-1.878	.009	<.001	3	4
CNS	UBAP2 →	-0.391	-1.006	.001	<.001	3	4
CNS	TLCD1 →	-1.387	-0.999	.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	DCAF10 →	-1.644	-1.806	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CSKMT by Endoplasmic reticulum tubular network organization activity — BONE

Explore this box plot interactively →