Response to fibroblast growth factor

Across TCGA cell cohorts, RNA activity of the Response to fibroblast growth factor pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFIT3, SPRN, and KIFC3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to fibroblast growth factor activity versus IFIT3 in OESOPHAGUS (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	IFIT3 →	+2.532	+0.377	<.001	<.001	3	6
PANCREAS	SPRN →	-0.909	-0.409	<.001	.005	3	6
BLOOD_Leukemia	KIFC3 →	+1.421	+0.171	.002	<.001	3	5
OESOPHAGUS	IFIT2 →	+2.684	+0.345	<.001	.003	3	5
BLOOD_Leukemia	ANXA1 →	+2.686	+0.174	<.001	<.001	3	4
LIVER	PLXNB1 →	-3.082	-0.475	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071774 vs IFIT3 — OESOPHAGUS

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