Nuclear membrane organization

Across TCGA patient cohorts, RNA activity of the Nuclear membrane organization pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLEKHA7_S907, ADD2_S592, and MAP1B_S1965, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear membrane organization activity versus PLEKHA7_S907 in UCEC (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLEKHA7_S907 →	-0.362	-0.048	.003	.003	3	6
CCRCC	ADD2_S592 →	+0.763	+0.040	.001	<.001	3	6
CCRCC	MAP1B_S1965 →	+0.540	+0.036	.001	.001	3	6
BRCA	UCHL1 →	+0.984	+0.028	<.001	.007	3	6
BRCA	GMPR2 →	-0.282	-0.035	<.001	<.001	3	5
LSCC	MAP1B_S1427 →	+1.022	+0.029	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071763 vs PLEKHA7_S907 — UCEC

Explore this scatter interactively →