Nuclear membrane organization

Across TCGA pan-cancer cohorts, RNA activity of the Nuclear membrane organization pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 44 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Nuclear membrane organization pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and COAD, show the opposite pattern, with higher activity associated with better survival.

KIRP, KIRC, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.565	0.780	<.001	152	view →
KIRC	OS	Median	All	0.558	0.694	<.001	131	view →
ACC	OS	Median	All	0.764	0.955	<.001	108	view →
BLCA	DFS	Tertile	All	0.369	0.696	<.001	82	view →
LIHC	OS	Tertile	All	0.555	0.756	<.001	74	view →
UVM	DFS	Tertile	III,IV	0.207	0.797	.002	65	view →
LGG	DFS	Median	All	0.625	0.806	<.001	54	view →
READ	OS	Tertile	II,III,IV	0.876	0.263	<.001	36	view →
UCEC	DFS	Tertile	All	0.619	0.722	.005	28	view →
KICH	DFS	Quartile	All	0.761	1.000	.018	27	view →
COAD	OS	Tertile	II,III,IV	0.959	0.762	.005	26	view →
SCLC	OS	Median	All	0.612	0.360	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0071763–KIRP (OS)

Open the KIRP breakdown →