Nuclear membrane organization

Across TCGA patient cohorts, RNA activity of the Nuclear membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC01624, H4C4, and MCF2L, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear membrane organization activity versus LINC01624 in PDAC (Pearson r = -0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LINC01624 →	-0.364	-0.096	<.001	.001	3	3
LUAD	H4C4 →	-1.024	-0.158	<.001	.002	3	3
CCRCC	MCF2L →	-0.521	-0.155	.002	<.001	3	3
CCRCC	NTRK2 →	-0.671	-0.120	.009	.009	3	3
CCRCC	HNRNPDL →	-0.260	-0.211	<.001	<.001	3	3
CCRCC	PLCL2 →	-0.471	-0.223	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071763 vs LINC01624 — PDAC

Explore this scatter interactively →