Nuclear membrane organization

Across TCGA cell cohorts, RNA activity of the Nuclear membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC20, OSBP2, and SAAL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDC20 grouped by Nuclear membrane organization-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CDC20 →	-1.266	-0.237	.003	.006	3	4
OESOPHAGUS	OSBP2 →	+1.469	+0.192	.004	<.001	3	4
LUNG_SCLC	SAAL1 →	+0.754	+0.247	.005	<.001	3	4
LUNG_SCLC	ZNF623 →	+0.639	+0.184	.009	.001	3	4
LUNG_SCLC	DGKD →	+0.903	+0.215	.005	.001	3	4
SKIN	NUP93 →	-0.459	-0.153	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDC20 by Nuclear membrane organization activity — URINARY_TRACT

Explore this box plot interactively →