Nuclear membrane organization

Across TCGA cell cohorts, RNA activity of the Nuclear membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOR1A, TOR1B, and SPTLC1, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear membrane organization activity versus TOR1A in CNS (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TOR1A →	+0.722	+0.062	<.001	<.001	3	17
STOMACH	TOR1B →	+1.123	+0.117	<.001	<.001	3	15
BLOOD_Myeloma	SPTLC1 →	+0.865	+0.074	.002	.003	3	14
STOMACH	SPIN1 →	+1.124	+0.083	<.001	.002	3	13
BLOOD_Lymphoma	STX17 →	+0.775	+0.048	<.001	<.001	3	13
SOFT_TISSUE	RAB14 →	+0.722	+0.071	.002	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071763 vs TOR1A — CNS

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