Nuclear membrane organization

Across TCGA cell cohorts, RNA activity of the Nuclear membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUT1, THTPA, and TDP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear membrane organization activity versus TUT1 in CNS (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TUT1 →	+0.719	+0.234	<.001	<.001	3	8
LUNG_SCLC	THTPA →	+0.836	+0.194	<.001	<.001	3	7
BLOOD_Myeloma	TDP1 →	+1.116	+0.291	<.001	<.001	3	6
BREAST	ZNHIT3 →	+0.572	+0.115	.001	.008	3	6
SOFT_TISSUE	HIRIP3 →	+1.363	+0.270	.008	.009	3	6
BREAST	MRPL34 →	+0.849	+0.179	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071763 vs TUT1 — CNS

Explore this scatter interactively →