Leukotriene transport

Across TCGA patient cohorts, RNA activity of the Leukotriene transport pathway is significantly associated with the RNA expression of multiple genes, with the ESCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCC3, ABCC4, and ABCC10, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukotriene transport activity versus ABCC3 in ESCA (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	ABCC3 →	+1.814	+0.085	<.001	<.001	3	24
CHOL	ABCC4 →	+1.318	+0.112	.006	.005	1	25
THYM	ABCC10 →	+0.565	+0.041	<.001	<.001	3	18
THYM	ATP11A →	+0.845	+0.030	<.001	<.001	3	18
BLCA	RNY3P8 →	+1.180	+0.081	<.001	<.001	3	17
KIRC	PABPC1L →	+0.995	+0.045	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071716 vs ABCC3 — ESCA

Explore this scatter interactively →