Leukotriene transport

Across TCGA patient cohorts, RNA activity of the Leukotriene transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANXA4, RUFY1, and WRNIP1_S153, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukotriene transport activity versus ANXA4 in GBM (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ANXA4 →	+0.593	+0.100	.002	.001	3	6
GBM	RUFY1 →	+0.189	+0.070	.004	.007	3	5
OV	WRNIP1_S153 →	-0.809	-0.065	.007	.003	3	5
LSCC	CES1 →	+1.015	+0.080	<.001	<.001	3	5
GBM	CTDSPL2 →	-0.402	-0.099	.008	.001	3	5
COAD	AMACR →	+0.880	+0.054	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071716 vs ANXA4 — GBM

Explore this scatter interactively →